Endocrine Abstracts

Objective: Recent evidence reports a controversial extra-gonadal role of follicle stimulating hormone (FSH). Conflicting data support that the association between FSH and obesity might be maintained by a direct or even indirect effect to the adipose tissue. The aim of this study was to evaluate the associations between FSH concentrations and various obesity indices in women after menopause.Methods: This cross-sectional study included 420 postmenopausal w...

Objective: Differences in body weight and clinical features of typical vs atypical anorexia nervosa (A.N) might be explained by the genetic background. We aimed to evaluate the association between the subtypes of A.N. and the genetic polymorphisms of the thrombotic panel or the methyltetrahydrofolate reductase (MTHFR) gene.Methods: A total of 40 adolescent girls with A.N., aged 13–19 years, were evaluated. We recorded anthropometric parameters, amen...

Introduction: The aim of this study was to evaluate predictors of metabolic disease in normal weight postmenopausal women.Patients and Methods: This cross-sectional study included 457 non-obese postmenopausal women, recruited from the Menopause Clinic of Aretaieio Hospital, National and Kapodistrian University of Athens. The diagnostic criteria of the International Diabetes Federation for the definition of Metabolic Syndrome were used, in order to classi...

Introduction: Recent evidence reports a controversial extra-gonadal role of follicle stimulating hormone (FSH). Conflicting data support that the association between FSH and obesity might be maintained by a direct or even indirect effect to the adipose tissue. The aim of this study was to evaluate the associations between FSH concentrations and various obesity indices in women after menopause.Patients and Methods: This cross-sectional study included 420 ...

Objective: Menopausal transition has been associated with an increased risk of cardiovascular disease (CVD), mainly attributed to atherogenic dyslipidaemia, central obesity and insulin resistance. Whether arterial hypertension (AH) also contributes to menopause-associated CVD is currently unknown. The aim of this study was to systematically investigate and meta-analyze the best available evidence regarding the association between early menopause (EM) and AH risk.<p class="...

Introduction: The hypothalamic-pituitary-ovarian and/or adrenal axis as well as the autonomous nervous system affect significantly the intensity of menopausal symptoms Pre-existing levels of stress may affect the individual perception of menopausal symptoms. We aimed to evaluate the efficacy of a structured stress management program to reduce levels of stress and severity of climacteric symptoms, in a sample of middle-aged Greek women.Methods: The sample...

Objective: To investigate the effect of two hormone therapy (HT) regimens differing only in their progestin component on serum markers of apoptosis.Design: Randomized, double-blinded study.Patients: One hundred healthy postmenopausal women.Interventions: Patients were randomized to 17β-estradiol 1 mg/drosperinone 2 mg (E2/DSP) or 17β-estradiol 1 mg/norethisterone acetate 0.5 mg (E2</...

Background/aim: The role of neutrophils and platelets in atherothrombotic disease is well established. The aim of our study was to investigate the effect of hormone therapy and tibolone on the soluble markers of neutrophil and platelet activation, ADAM-8 and CD40L respectively, in healthy postmenopausal women.Subjects and methods: One hundred and six healthy postmenopausal women were randomly allocated to: estradiol plus drospirenone (E2/DSP),...

IntroductionRecent evidence suggests a possible link between prediabetes and lower density in postmenopausal populations. Moreover, earlier data suggest a link between diagnosis of diabetes and lower levels of bone density in women after the menopausal transition. We aimed to evaluate the possible association between insulin resistance and a diagnosis of lumbar or hip osteoporosis and/or prevalent fractures of the lumbar spine. Met...

IntroductionMenopausal transition is associated with an increase in the cardiovascular risk, possibly related with the sharp decrease of estrogen levels. Menopausal symptoms and more specifically hot flushes have been previously linked with an increase in cardiovascular risk. On the other hand, non-alcoholic fatty liver disease is considered as another presentation of the metabolic syndrome, conferring additional cardiovascular risk to the affected indiv...